A pulse sequence is a preselected set of defined RF and gradient pulses, usually repeated many times during a scan, wherein the time interval between pulses and the amplitude and shape of the gradient waveforms will control NMR signal reception and affect the characteristics of the MR images. Pulse sequences are computer programs that control all hardware aspects of the MRI measurement process.
Usual to describe pulse sequences, is to list the repetition time (TR), the echo time (TE), if using inversion recovery, the inversion time (TI) with all times given in milliseconds, and in case of a gradient echo sequence, the flip angle. For example, 3000/30/1000 would indicate an inversion recovery pulse sequence with TR of 3000 msec., TE of 30 msec., and TI of 1000 msec.
Specific pulse sequence weightings are dependent on the field strength, the manufacturer and the pathology.

See also Interpulse Times.

A surface coil placed over a region of interest will have an effective selectivity for a volume approximately subtended by the coil circumference and one radius deep from the coil center. Such a coil can be used for simple localization of sites for measurement of chemical shift spectra, especially of phosphorus, and blood flow studies. Some additional spatial selectivity can be achieved with magnetic field gradients.

Diffusion weighted imaging can be performed similar to the phase contrast angiography sequence. The gradients must be increased in amplitude to depict the much slower motions of molecular diffusion in the body.
While a T1 weighted MRI pulse sequence is diffusion sensitive, a quantitative diffusion pulse sequence was introduced by Steijskal and Tanner. Its characteristic features are two strong symmetrical gradient lobes placed on either side of the 180° refocusing pulse in a spin echo sequence. These symmetrical gradient lobes have the sole purpose of enhancing dephasing of spins, thereby accelerating intravoxel incoherent motion (IVIM) signal loss.
Dephasing is proportional to the square of the time (diffusion time) during which the gradients are switched on and the strength of the applied gradient field. Therefore, the use of high field gradient systems with faster and more sensitive sequences, make diffusion weighting more feasible.
Areas in which the protons diffuse rapidly (swollen cells in early stroke, less restriction to diffusion) will show an increased signal when the echo is measured relative to areas in which diffusion is restricted. For increased accuracy of diffusion measurement and image enhancement, useful motion correction techniques such as navigator echo and other methods should be used. In addition to this, applying the b-value calculated by the strength and duration of motion probing gradients with a high rate of accuracy is very important.

See also Apparent Diffusion Coefficient, ADC Map, Lattice Index Map.

Motion of material being imaged, particularly flowing blood, can result in many possible effects in the images.
Fast moving blood produces flow voids, blood flowing in to the outer slices of an imaging volume produces high signals (flow related enhancement, entry slice phenomenon), pulsatile flow creates ghost images of the vessel extending across the image in the phase encoding direction (image misregistration).
Flow-related dephasing occurring when spin isochromats are moving with different velocities in an external gradient field G so that they acquire different phases. When these phases vary by more then 180° within a voxel, substantial spin dephasing results leading to considerable intravascular signal loss.
These effects can be understood as caused by time of flight effects (washout or washin due to motion of nuclei between two consecutive spatially selective RF excitations, repeated in times on the order of, or shorter than the relaxation times of blood) or phase shifts (delay between phase encoding and frequency encoding) that can be acquired by excited spins moving along magnetic field gradients.
The inconsistency of the signal resulting from pulsatile flow can lead to artifacts in the image. The flow effects can also be exploited for MR angiography or flow measurements.

See also Flow Artifact.

Partial averaging is a scan time reduction method that takes advantage of the complex conjugate of the k-space. The number of phase encoding steps of the acquisition matrix are reduced in the phase encoding direction.
Since negative values of phase encoded measurements are identical to corresponding positive values, only a little over half (more than 62.5%) of a scan actually needs to be acquired to replicate an entire scan. This results in a reduction in scan time at the expense of signal to noise ratio. The time reduction can be nearly a factor of two, but full resolution is maintained.
Partial Fourier averaging can be used when scan times are long, the signal to noise ratio is not critical and where full spatial resolution is required. Partial averaging is particularly appropriate for scans with a large field of view and relatively thick slices; and in 3D scans with many slices. In some fast scanning techniques the use of partial averaging enables a shorter TE thus improving contrast.
Partial averaging is also called Fractional NEX, Half Scan, Half Fourier, Phase Conjugate Symmetry, Single Side Encoding.